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KMID : 0387919950060020163
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Korean Journal of Cytopathology
1995 Volume.6 No. 2 p.163 ~ p.168
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Effusion
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이미숙
이미자/정유경/임성철/기근홍/전호종
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Abstract
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Ki-1 positive anaplastic large cell lymphoma is newly described high-grade lymphoma and is defined by histopathological and immunologic criteria. We experienced a case of systemically systemically involving Ki-1 positive anaplastic
large
cell lymphoma in a 44 yearold female which initially manifested as pleural effusion. Abdominopelvic CT scan showed
the evidence of marked lymphadenopathy in retroperitoneal and both external and inguinal lymph nodes.
On cytologic examination of pleural fluid tumor cells revealed pleomorphic large isolated cells with prominent nucleoli and abundant cytoplasms. The nuclei were large with irregular profiles including some deep invaginations. Also.
occasional multilobed/multinucleated and binucleated nuclei were seen. Immunohistochemical examination was performed to differentiate from the undifferentiated adenocarcinoma. Hodgkin's disease, non-Hodgkin's lymphoma and malignant
histiocytosis.
The neoplastic cells were positive for leukocyte common antigen. CD3 CD30(ki-1) but negative for cytokeratin. epithelial membrane antigen. and CD15. A histologic diagnosis of Ki-1 positive anaplastic lymphoma was made by biopsies of the
inguinal
lymph node, polypoid lesion of the stomach and cecum.
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